For some vaccines, administration should
not be done at different time intervals. The live parenteral (injected)
vaccines (MMR, MMRV, varicella, zoster, and yellow fever) and live intranasal
influenza vaccine (LAIV should be separated by at least 4 weeks. This interval
is intended to reduce or eliminate interference from the vaccine. The yellow
fever vaccine Should be administered less than 4 weeks after the single-antigen
measles vaccine. A 1999 study demonstrated that the yellow fever vaccine is not
affected by the measles vaccine given 1–27 days earlier. Live vaccines
administered by the oral route (oral polio vaccine [OPV] oral typhoid, and
rotavirus) are not believed to interfere with each other if not given
simultaneously. These vaccines may be given at any time before or after each
other. The Rotavirus vaccine is not approved for children older than 32 weeks, and oral
typhoid is not approved for children younger than 6 years of age.
Parenteral live vaccines (MMR, MMRV, varicella, zoster, and yellow fever) and LAIV are not believed to have an effect on live vaccines given by the oral route (OPV, oral typhoid, and rotavirus). Live oral vaccines may be given at any time before or after live parenteral vaccines or LAIV. All other combinations of two inactivated vaccines, or live and inactivated vaccines, may be given at any time before or after each other.